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PubMed · 8380546

Epstein-Barr virus and CD30+ malignant lymphomas.

H Herbst·H Stein·G Niedobitek
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Abstract

Phenotypic, genotypic, and karyotypic analyses have indicated that Hodgkin's disease and CD30+ anaplastic large cell lymphoma may be conceived as malignancies derived from activated, cytokine-producing lymphoid cells, in many instances with an immature genotype. Most recently, Epstein-Barr virus (EBV) genomes and gene products, most notably the transformation-associated latent membrane protein (LMP), have been detected in approximately 50 and 20% of the cases, respectively. These findings suggest that EBV may superimpose an activated phenotype on an immature lymphoid cell, contributing to the pathoetiology of sizable proportions of these CD30+ malignancies.

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Antigens, CDAntigens, NeoplasmChromosome AberrationsCytokinesFemaleGene ExpressionGene RearrangementGenes, ImmunoglobulinGenome, ViralHerpesvirus 4, HumanHodgkin DiseaseHumansKaryotypingKi-1 AntigenLymphoma, Large B-Cell, DiffuseMaleOncogenesProto-OncogenesReceptors, AntigenJournal ArticleResearch Support, Non-U.S. Gov'tReview

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H Herbst, H Stein, G Niedobitek. 1993. Epstein-Barr virus and CD30+ malignant lymphomas.. https://pubmed.ncbi.nlm.nih.gov/8380546/

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