The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.

M J Farrell; J M Hill; T P Margolis; J G Stevens; E K Wagner; L T Feldman

doi:10.1128/jvi.67.6.3653-3655.1993

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The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.

M J Farrell·J M Hill·T P Margolis·J G Stevens·E K Wagner·L T Feldman

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Abstract

The latency-associated transcription unit has been shown to be important for in vivo reactivation of herpes simplex virus from the latent state. A recombinant virus was constructed to alter the largest open reading frame in this region. This virus had a wild-type reactivation phenotype, suggesting that herpes simplex virus does not require a protein function from this reading frame for efficient reactivation from latency.

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DNA, Recombinant DNA, Viral Mutagenesis, Insertional Open Reading Frames Simplexvirus Transcription, Genetic Virus Activation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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M J Farrell, J M Hill, T P Margolis, J G Stevens, E K Wagner, L T Feldman. 1993. The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.. https://doi.org/10.1128/jvi.67.6.3653-3655.1993

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