Gamma delta T-cell development.

J P Allison

doi:10.1016/0952-7915(93)90011-g

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PubMed · 8389558

Gamma delta T-cell development.

J P Allison

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Abstract

Gamma delta T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programmed rearrangement of V gamma-gene segments. It appears that the T-cell receptor repertoire, at least of the gamma delta T cells with invariant receptors, is the result of site-directed rearrangement and cellular selection does not play a major role.

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Animals Cell Differentiation Gene Rearrangement, delta-Chain T-Cell Antigen Receptor Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Mice Mice, Mutant Strains Models, Biological Receptors, Antigen, T-Cell, gamma-delta Signal Transduction T-Lymphocyte Subsets Thymus Gland Journal Article Review

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J P Allison. 1993. Gamma delta T-cell development.. https://doi.org/10.1016/0952-7915(93)90011-g

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