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PubMed · 8389719

Recombinant GABAA receptor function and ethanol.

E Sigel·R Baur·P Malherbe
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Abstract

Different combinations of cloned subunits of the rat brain GABAA receptor were expressed in Xenopus oocytes. Possible effects of ethanol on the expressed GABA-induced chloride current were determined. The consequence of replacing the gamma 2S subunit by the alternatively spliced variant gamma 2L was specifically tested on the responsiveness to ethanol. A significant stimulation of the GABA response was only observed at very high concentrations (> 60 mM) of ethanol. No differential response was observed between subunit combinations containing different gamma 2 subunit splice variants.

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Alternative SplicingAnimalsChloride ChannelsElectric ConductivityEthanolMembrane ProteinsOocytesRatsReceptors, GABA-ARecombinant ProteinsXenopusJournal ArticleResearch Support, Non-U.S. Gov't

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E Sigel, R Baur, P Malherbe. 1993-06-14. Recombinant GABAA receptor function and ethanol.. https://doi.org/10.1016/0014-5793(93)81380-i

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