Humanized antibodies.

G Winter; W J Harris

doi:10.1016/0167-5699(93)90039-n

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PubMed · 8397764

Humanized antibodies.

G Winter·W J Harris

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Abstract

Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.

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Animals Antibodies, Monoclonal Computer Simulation Genes, Immunoglobulin Humans Immunotherapy Protein Engineering Protein Structure, Tertiary Journal Article Review

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G Winter, W J Harris. 1993. Humanized antibodies.. https://doi.org/10.1016/0167-5699(93)90039-n

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