[Platelet functions in atherosclerosis].

Abstract

Recent advances on platelet functions involved in atherosclerosis and subsequent thromboembolic diseases are reviewed. Platelets show multiple roles in hemostasis/thrombosis, wound healing, allergy, inflammation, metastasis of malignant cells and vasospasms through aggregation/secretion reaction. In atheromatous plaque, migration and proliferation of vascular smooth muscle cells and macrophages are the most prominent findings. In this pathological state, platelet may play as an enhancer by the secretion of bioactive substances including platelet-derived growth factor, serotonin and platelet factor 4. Investigation on platelet dynamics must be carried out not only for monitoring but also for the assessment of progressive factors in atherosclerotic disease.