Naltrexone does not increase brain and body development in rats.

B F Petrie

doi:10.1016/0892-0362(93)90009-d

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Naltrexone does not increase brain and body development in rats.

B F Petrie

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Abstract

Two strains of preweanling rats (88 Long-Evans; 120 Sprague-Dawley) were given daily SC injections of either 50 mg/kg naltrexone or the equivalent volume of saline, from birth to postnatal day 21. Brain and body weights were assessed at the end of the injections, and in Long-Evans animals, significant differences were noted on both measures with the outcome favoring the control animals. No significant differences were observed between the naltrexone and control Sprague-Dawley rats. These results disconfirm the hypothesis that increased postnatal growth is accomplished by prolonged early postnatal opioid receptor blockade.

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Animals Animals, Newborn Body Weight Brain Female Growth Injections, Subcutaneous Male Naltrexone Organ Size Rats Rats, Sprague-Dawley Species Specificity Comparative Study Journal Article

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B F Petrie. Naltrexone does not increase brain and body development in rats.. https://doi.org/10.1016/0892-0362(93)90009-d

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