An association between hypothyroidism and primary open-angle glaucoma.

K D Smith; B P Arthurs; N Saheb

doi:10.1016/s0161-6420(93)31441-7

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An association between hypothyroidism and primary open-angle glaucoma.

K D Smith·B P Arthurs·N Saheb

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Abstract

PURPOSE: To test the hypothesis that there is an association between hypothyroidism and primary open-angle glaucoma. METHODS: The study was conducted in a case-control fashion. Sixty-four patients with primary open-angle glaucoma were evaluated for hypothyroidism by history and by undergoing a thyroid-stimulating hormone immunoradiometric assay. Sixty-four control subjects from the general eye clinic were evaluated in the same manner. Patients found to have elevated thyroid-stimulating hormone immunoradiometric assay were evaluated by an endocrinologist for hypothyroidism. RESULTS: Of the primary open-angle glaucoma group, 23.4% had hypothyroidism. A diagnosis was made previously in 12.5% patients, and 10.9% were newly diagnosed. Of the control subjects, 4.7% had hypothyroidism. A diagnosis had been made previously in 1.6% of the control subjects, and 3.1% were newly diagnosed. The difference between the two groups was found to be statistically significant. CONCLUSION: A statistically significant association between hypothyroidism and primary open-angle glaucoma is demonstrated. There is a large group (10.9%) of patients with primary open-angle glaucoma with undiagnosed hypothyroidism.

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K D Smith, B P Arthurs, N Saheb. 1993. An association between hypothyroidism and primary open-angle glaucoma.. https://doi.org/10.1016/s0161-6420(93)31441-7

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