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Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin.

I A Belokopytova·E I Kostyleva·A N Tomilin·V I Vorob'ev
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Abstract

Basic chromosomal proteins were extracted from the sperm of fertile and infertile human males. The relative proportions of protamine 1, 2, and 3 were determined by scanning microdensitometry following electrophoresis of total protamine in polyacrylamide gels. The findings were as follows: (1) The proportion of protamine P(2 + 3) in sperm obtained from infertile males was lower than that in fertile males. (2) Protamine P(2 + 3) in infertile human males showed reduced affinity to DNA. The possibility that some cases of human male infertility may be due to mutation within the protamine P2 gene is discussed.

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ChromatinGene Expression RegulationHumansInfertility, MaleMaleProtaminesRNA, MessengerSpermatozoaJournal Article

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I A Belokopytova, E I Kostyleva, A N Tomilin, V I Vorob'ev. 1993. Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin.. https://doi.org/10.1002/mrd.1080340109

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