Dendritic epidermal T cells: lessons from mice for humans.

P R Bergstresser; P D Cruz; A Takashima

doi:10.1111/1523-1747.ep12356076

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Dendritic epidermal T cells: lessons from mice for humans.

P R Bergstresser·P D Cruz·A Takashima

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Abstract

Dendritic epidermal T cells (DETC) in mice form part of a primitive system of epithelial-resident T cells characterized by the expression of gamma delta T-cell receptors (TCR). Critical attributes that characterize DETC include their highly restricted T-cell receptor gene utilization, proliferation and maturation within epidermis, a capacity to kill relevant skin-derived tumor targets, and the ability to modulate immune responses that are initiated and expressed in skin. Contemporary knowledge suggests that DETC and the related skin-directed gamma delta T cells found in humans play important roles in maintaining the immunologic integrity of skin.

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Animals Cell Line Dendritic Cells Epidermal Cells Humans Mice Phenotype Receptors, Antigen, T-Cell, gamma-delta Skin Diseases T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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P R Bergstresser, P D Cruz, A Takashima. 1993. Dendritic epidermal T cells: lessons from mice for humans.. https://doi.org/10.1111/1523-1747.ep12356076

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