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PubMed · 8427678

Systemic osteoclast activation by localized pressure.

D E Wolfman·S P Tinling
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Abstract

It has been demonstrated that positive air pressure applied to the bulla of the Mongolian gerbil results in significant osteoclastic activation and bone resorption. In this study, continuous positive air pressure of 15 mm Hg was applied to the right bulla for 1 week. A significant increase in osteoclast number and surface were noted in the contralateral, unpressurized bulla as well as in a distant site, the upper extremity (radius). Possible mechanisms are discussed by which a local stimulus (pressure) may cause distant osteoclast activation.

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Air PressureAnimalsBiopsyBody Surface AreaBone ResorptionCholesteatomaCytokinesDisease Models, AnimalEar, MiddleEvaluation Studies as TopicGerbillinaeMaleOsteoclastsProstaglandinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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D E Wolfman, S P Tinling. 1993. Systemic osteoclast activation by localized pressure.. https://doi.org/10.1001/archotol.1993.01880140047008

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PubMed2006

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