Copper uptake and resistance in bacteria.

D A Cooksey

doi:10.1111/j.1365-2958.1993.tb01091.x

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Copper uptake and resistance in bacteria.

D A Cooksey

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Abstract

Copper ions are essential for bacteria but can cause a number of toxic cellular effects if levels of free ions are not controlled. Investigations of copper-resistant bacteria have revealed several mechanisms, mostly plasmid-determined, that prevent cellular uptake of high levels of free copper ions. However, these studies have also revealed that bacteria apparently have efficient chromosomally encoded systems for uptake and management of trace levels of copper. This review will explore the relationship of copper uptake systems to resistance mechanisms and the possibility that copper resistance has evolved directly through modification of chromosomal copper uptake genes.

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Amino Acid Sequence Bacteria Biological Transport Copper Drug Resistance Escherichia coli Genes, Bacterial Molecular Sequence Data Operon Pesticides Pseudomonas Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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D A Cooksey. 1993. Copper uptake and resistance in bacteria.. https://doi.org/10.1111/j.1365-2958.1993.tb01091.x

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