Thyrotropin receptor in non-thyroid tissues.

T Endo; M Ohno; S Kotani; K Gunji; T Onaya

doi:10.1006/bbrc.1993.1116

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Thyrotropin receptor in non-thyroid tissues.

T Endo·M Ohno·S Kotani·K Gunji·T Onaya

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Abstract

Thyrotropin receptor (TSH-R), the main target for the autoantibody in Graves' disease, has been thought to be a thyroid-specific protein. However, we successfully obtained the cDNA fragments of TSH-R from rat retro-orbital tissues and adipose tissues by using polymerase chain reaction methods. Sequencing has revealed that the nucleotide sequence of the cDNAs from these non-thyroid tissues was identical to that from the thyroid. TSH-R peptide antibody, which recognizes rat TSH-R, stained a 104 kDa protein from the retro-orbital tissues and the adipose tissues. The band was not detected with the antibody preabsorbed with the peptide. These results suggest that the message is translated to make a TSH-R protein even in these non-thyroid tissues.

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Animals Base Sequence Gene Expression Male Molecular Sequence Data Oligodeoxyribonucleotides Polymerase Chain Reaction RNA, Messenger Rats Rats, Wistar Receptors, Thyrotropin Tissue Distribution Journal Article

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T Endo, M Ohno, S Kotani, K Gunji, T Onaya. 1993-02-15. Thyrotropin receptor in non-thyroid tissues.. https://doi.org/10.1006/bbrc.1993.1116

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