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PubMed · 8449242

[Androgen-dependent tumor].

J Shimazaki·Y Furuya·N Sato·T Ichikawa
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Abstract

Androgen receptor is necessary for the proliferation of androgen-dependent tumors including human prostatic cancer and murine androgen-sensitive tumors. However, androgen-independent tumor containing functional androgen receptor was observed in CS 2 cells, which is a subline of androgen-dependent mouse tumor (SC 115). CS 2 showed a new expression of hst-1, the product of which is a family of FGF. CS 2 secreted a growth factor which promotes growth of CS 2 and original SC 115 in an autocrine and paracrine manner. The role of oncogene(s) and suppressor gene(s) on the progression of the tumor is discussed.

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AndrogensAnimalsCell DivisionGrowth SubstancesHumansMaleMiceNeoplasms, Hormone-DependentProstatic NeoplasmsRatsReceptors, AndrogenTumor Cells, CulturedEnglish AbstractJournal ArticleReview

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BibTeXRIS

J Shimazaki, Y Furuya, N Sato, T Ichikawa. 1993-01-20. [Androgen-dependent tumor].. https://doi.org/10.1507/endocrine1927.69.1_16

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