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PubMed · 8453274

Cyclin D and oncogenesis.

T Motokura·A Arnold
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Abstract

The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.

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AdenomaBreast NeoplasmsCarcinoma, Squamous CellCell CycleCell DivisionCell Transformation, NeoplasticCyclin D1CyclinsGene Expression Regulation, NeoplasticHumansLeukemia, B-CellLymphoma, B-CellMultigene FamilyOncogene ProteinsParathyroid NeoplasmsProto-Oncogene MasProto-OncogenesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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T Motokura, A Arnold. 1993. Cyclin D and oncogenesis.. https://doi.org/10.1016/s0959-437x(05)80334-x

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