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Long-term sweat collection using salt-impregnated pads.

M Phillips·R E Vandervoort·C E Becker
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Abstract

To facilitate a study of the pharmacokinetics of drugs dissolved in sweat, a technique was devised for collecting sweat at a steady rate over an 8-day period. Three normal subjects each wore 4 absorbent pads applied to their skin under waterproof dressings for 8 days. The absorbent pads were either plain cotton or cotton impregnated with sodium chloride crystals. Each pad (3 cm x 3 cm) was applied to an area of skin (2 cm x 2 cm) defined by an adhesive template, and was removed daily, weighed, and replaced, to determine progressive uptake of sweat. Sweat uptake by plain cotton pads reached a plateau value within 2 to 3 days and did not significantly increase thereafter; in contrast, uptake by the salt-impregnated pads continued at a steady rate for the full 8 days of the study (mean rate 0.79 mg/cm2/hr, SD = 0.16, N = 6). This effect may be related to an osmotic gradient across the skin, but the physiologic mechanisms are not completely clear. This appears to be a convenient tool for the collection of sweat over long periods at a steady rate.

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HumansSecretory RateSodium ChlorideSweatSweatingJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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BibTeXRIS

M Phillips, R E Vandervoort, C E Becker. 1977. Long-term sweat collection using salt-impregnated pads.. https://doi.org/10.1111/1523-1747.ep12493246

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