Immunomodulation with soluble IFN-gamma receptor: preliminary study.

L Ozmen; M Fountoulakis; R Gentz; G Garotta

doi:10.1016/b978-0-12-364935-5.50014-6

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Immunomodulation with soluble IFN-gamma receptor: preliminary study.

L Ozmen·M Fountoulakis·R Gentz·G Garotta

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Abstract

Several in vivo experiments support the hypothesis that an IFN-gamma antagonist may have therapeutic applications in autoimmune diseases, hypersensitivities, and alloreactions. IFN-gamma exerts its biological activity through the binding to a single-chain cell surface receptor. The protein that corresponds to the external domain of mouse IFN-gamma receptor was expressed in insect cells infected with recombinant baculovirus; this protein was characterized and used in vivo as a prototype of the IFN-gamma antagonist. This protein does not show any strong antigenicity after in vivo injection in mice. Despite a blood half-life of only 1-3 hr as demonstrated in pharmacokinetic experiments, the mouse soluble IFN-gamma R was able to modify the onset of acute GVHD (alloreaction) and chronic GVHD (lupuslike disease).

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Acute Disease Adjuvants, Immunologic Amino Acid Sequence Animals Chronic Disease Graft vs Host Disease Interferon-gamma Mice Mice, Inbred C57BL Mice, Inbred DBA Molecular Sequence Data Pharmacokinetics Receptors, Interferon Solubility Interferon gamma Receptor Journal Article

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L Ozmen, M Fountoulakis, R Gentz, G Garotta. 1993. Immunomodulation with soluble IFN-gamma receptor: preliminary study.. https://doi.org/10.1016/b978-0-12-364935-5.50014-6

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