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PubMed · 8459209

Thymus epithelium induces tissue-specific tolerance.

A Bonomo·P Matzinger
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Abstract

Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells.

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AnimalsEpitheliumFemaleImmune ToleranceMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, NudeMice, TransgenicOrgan SpecificityPregnancySpleenT-LymphocytesThymus GlandJournal Article

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A Bonomo, P Matzinger. 1993-04-01. Thymus epithelium induces tissue-specific tolerance.. https://doi.org/10.1084/jem.177.4.1153

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