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Diffusion imaging of experimental allergic encephalomyelitis.

A C Heide·T L Richards·E C Alvord·J Peterson·L M Rose
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Abstract

Diffusion-weighted magnetic resonance imaging (MRI) was compared with T2-weighted MRI in longitudinal studies of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, in five monkeys (Macaca fascicularis). In a region of the brain that had highly directional myelinated fibers (internal capsule) sequential changes were identified on diffusion-weighted images on and before the day these changes were detected on conventional T2-weighted images. Changes were also identified on diffusion-weighted images in brain areas that did not develop T2-weighted abnormalities. This result suggests that diffusion-weighted image intensities are sensitive to pathologic conditions of the brain that can not be seen on T2-weighted images.

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AnimalsBrainEncephalomyelitis, Autoimmune, ExperimentalMacaca fascicularisMagnetic Resonance ImagingMaleMultiple SclerosisComparative StudyJournal Article

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A C Heide, T L Richards, E C Alvord, J Peterson, L M Rose. 1993. Diffusion imaging of experimental allergic encephalomyelitis.. https://doi.org/10.1002/mrm.1910290409

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