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Bioassay from two parabolas.

M A Moussa
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Abstract

The paper deals with potency ratio estimation of parallel curve analytic dilution assays in case log dose-response relationship could be reasonably described by a parabola. It comprises: (1) testing the adequacy and validity of the quadratic model by the analysis of variance; and (2) estimation of the relative potency of an unknown in relation to a standard preparation, its standard deviation and fiducial limits for its true value. The method is applicable whenever successive doses of an unknown are a constant multiple of a standard in randomized blocks or completely randomized design. The method can be generalized to polynomial models of higher order.

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Analysis of VarianceBiasBiological AssayDose-Response Relationship, DrugEvaluation Studies as TopicLinear ModelsReproducibility of ResultsSoftware ValidationTherapeutic EquivalencyJournal Article

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BibTeXRIS

M A Moussa. 1993. Bioassay from two parabolas.. https://doi.org/10.1016/0010-4825(93)90109-e

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