Complement activation by polymethyl methacrylate minimized by end-point heparin attachment.

M Pekna; R Larsson; B Formgren; U R Nilsson; B Nilsson

doi:10.1016/0142-9612(93)90022-t

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Complement activation by polymethyl methacrylate minimized by end-point heparin attachment.

M Pekna·R Larsson·B Formgren·U R Nilsson·B Nilsson

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Abstract

After intraocular lens implantation, despite good clinical results, many cataract patients develop a chronic uveitis, caused by an inflammatory response to the implant. One way to improve the biocompatibility of the intraocular lens is to modify the surface by end-point heparin attachment. This study shows that complement activation caused by poly(methyl methacrylate) can be diminished by end-point heparin attachment, as demonstrated by a significant reduction in the generation of C3a and fluid phase terminal complement complexes. It suggests that assessment of complement activation is a good indicator of the biocompatibility of intraocular lenses.

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Biocompatible Materials Blotting, Western Complement Activation Complement C3c Complement Membrane Attack Complex Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Heparin Humans Lenses, Intraocular Methylmethacrylates Journal Article Research Support, Non-U.S. Gov't

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M Pekna, R Larsson, B Formgren, U R Nilsson, B Nilsson. 1993. Complement activation by polymethyl methacrylate minimized by end-point heparin attachment.. https://doi.org/10.1016/0142-9612(93)90022-t

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