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PubMed · 8481565

Clinical trials in multiple sclerosis.

J H Noseworthy
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Abstract

In this past year, there has only been modest progress in the search for an effective treatment for multiple sclerosis and its complications, although a number of carefully designed trials are in progress. No treatment predictably slows the course of active disease. The marginal benefits previously claimed for azathioprine have been strengthened by a meta-analysis of previously published work. Methylprednisolone may have a minor role in the treatment of very severe, acute optic neuritis but prednisone use may predispose patients to recurrent optic neuritis. 4-Aminopyridine and 3,4-diaminopyridine may prove useful for the symptomatic treatment of some multiple sclerosis patients; pemoline may be an alternative to amantadine for the control of fatigue; and acetazolamide may be an alternative to carbamazepine and phenytoin for the treatment of painful tonic spasms.

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Adrenal Cortex HormonesAnimalsClinical Trials as TopicDisability EvaluationHumansMultiple SclerosisNeurologic ExaminationJournal ArticleReview

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J H Noseworthy. 1993. Clinical trials in multiple sclerosis.. https://pubmed.ncbi.nlm.nih.gov/8481565/

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