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A method for testing the nonrandomness of chromosomal breakpoints.

J J Tai·C D Hou·S Wang-Wuu·C H Wang·S Y Leu·K D Wuu
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Abstract

Testing the nonrandomness of breakage at a chromosome band is an essential step fo identifying a fragile site. In this paper, we propose a method derived by using the relationship between the binomial and F distributions for testing nonrandomness. The method is simple in calculation. It was applied to the detection of fragile sites for Chinese patients with colorectal carcinoma.

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CarcinomaChinaChromosome AberrationsChromosome DisordersChromosome Fragile SitesChromosome FragilityChromosome MappingColorectal NeoplasmsDNA, NeoplasmHumansMetaphaseProbabilityJournal ArticleResearch Support, Non-U.S. Gov't

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J J Tai, C D Hou, S Wang-Wuu, C H Wang, S Y Leu, K D Wuu. 1993. A method for testing the nonrandomness of chromosomal breakpoints.. https://doi.org/10.1159/000133523

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