Nerve growth factor revisited.

R A Bradshaw; T L Blundell; R Lapatto; N Q McDonald; J Murray-Rust

doi:10.1016/0968-0004(93)90052-o

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PubMed · 8488558

Nerve growth factor revisited.

R A Bradshaw·T L Blundell·R Lapatto·N Q McDonald·J Murray-Rust

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Abstract

Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase, as a receptor and (3) it shares homology with at least three other factors, now collectively called neurotrophins, which have a spectrum of target cells.

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Amino Acid Sequence Animals Humans Molecular Sequence Data Nerve Growth Factors Protein Conformation Proto-Oncogene Mas Receptors, Nerve Growth Factor Structure-Activity Relationship Journal Article Review

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R A Bradshaw, T L Blundell, R Lapatto, N Q McDonald, J Murray-Rust. 1993. Nerve growth factor revisited.. https://doi.org/10.1016/0968-0004(93)90052-o

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