Structural characterization of terflavoxate.

A Leonardi; R Cappelletti; D Nardi; F Giordano

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PubMed · 8489568

Structural characterization of terflavoxate.

A Leonardi·R Cappelletti·D Nardi·F Giordano

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Abstract

Data are reported on the structural characterization of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 1,1-dimethyl-2-(N-piperidinyl)ethyl ester hydrochloride (terflavoxate-HCl, Rec 15/2053, CAS 86433-39-8), a new antispasmodic for the lower urinary tract. UV, IR, NMR and MS spectra fully confirmed the structure. The X-ray crystal structure determination revealed that the molecular structure consists of a rigid platform, formed by the chromone system, with two arms, the phenyl group at C(2) and the ester chain at C(8). The ester chain conformation generates a small hollow where two oxygen atoms face.

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Chemical Phenomena Chemistry, Physical Crystallization Flavoxate Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Conformation Parasympatholytics Spectrophotometry, Infrared Spectrophotometry, Ultraviolet X-Ray Diffraction Journal Article

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A Leonardi, R Cappelletti, D Nardi, F Giordano. 1993. Structural characterization of terflavoxate.. https://pubmed.ncbi.nlm.nih.gov/8489568/

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