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PubMed · 8502790

Upper confidence limits on excess risk for quantitative responses.

R L Kodell·R W West
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Abstract

The definition and observation of clear-cut adverse health effects for continuous (quantitative) responses, such as altered body weights or organ weights, are difficult propositions. Thus, methods of risk assessment commonly used for binary (quantal) toxic responses such as cancer are not directly applicable. In this paper, two methods for calculating upper confidence limits on excess risk for quantitative toxic effects are proposed, based on a particular definition of an adverse quantitative response. The methods are illustrated with data from a dose-response study, and their performance is evaluated with a Monte Carlo simulation study.

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AnimalsDose-Response Relationship, DrugFemaleHazardous SubstancesHumansIsoniazidModels, StatisticalMonte Carlo MethodProbabilityRatsRats, Inbred F344Risk FactorsWeight LossJournal Article

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BibTeXRIS

R L Kodell, R W West. 1993. Upper confidence limits on excess risk for quantitative responses.. https://doi.org/10.1111/j.1539-6924.1993.tb01067.x

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