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PubMed · 8503032

[Changes in endocochlear potential induced by potassium-channel blockers].

J Wang·Q H Li·W J Dong·J S Chen
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Abstract

The effect of various potassium-channel blockers, 4-aminopyridine (4-AP), tetraethylammonium (TEA) and quinine, on the endocochlear potential (EP) was studied in perfused guinea pig inner ears. The fast K(+)-channel blocker, 4-AP, did not alter EP but changed its response model to intense noise exposure. While TEA and quinine significantly reduced the amplitude of negative component of EP (N-EP), comparing with a relatively smaller increase in general EP (G-EP). The results indicated the existence of different K(+)-channels with different physiological functions.

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4-AminopyridineAnimalsCochleaCochlear Microphonic PotentialsFemaleGuinea PigsMalePotassium ChannelsQuinineTetraethylammoniumTetraethylammonium CompoundsEnglish AbstractJournal Article

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J Wang, Q H Li, W J Dong, J S Chen. 1993. [Changes in endocochlear potential induced by potassium-channel blockers].. https://pubmed.ncbi.nlm.nih.gov/8503032/

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