Peptide antigen presentation by non-classical MHC class I molecules.

K Fischer Lindahl

doi:10.1006/smim.1993.1015

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Peptide antigen presentation by non-classical MHC class I molecules.

K Fischer Lindahl

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Abstract

The mouse major histocompatibility complex contains more than 40 class I genes in addition to those encoding the classical class I molecules. Many of these encode functional class I heavy chains that are expressed and displayed on the cell surface in association with beta 2-microglobulin. Several laboratories, using genetic, biochemical, and molecular analysis, RMA-S mutant cells, and synthetic peptides, have recently shown that mouse non-classical or class Ib molecules present peptide antigens to T lymphocytes with alpha beta or gamma delta receptors. The class Ib genes, with their limited polymorphism, may have evolved to serve specialized presentation functions.

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Amino Acid Sequence Animals Antigens Heat-Shock Proteins Histocompatibility Antigens Class I Membrane Glycoproteins Mice Molecular Sequence Data Peptides Receptors, Antigen, T-Cell, gamma-delta T-Lymphocytes Journal Article Review

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K Fischer Lindahl. 1993. Peptide antigen presentation by non-classical MHC class I molecules.. https://doi.org/10.1006/smim.1993.1015

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