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PubMed · 8507492

Turning DNA replication on and off.

J M Roberts
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Abstract

DNA replication is coupled to cell cycle progression at a major regulatory point in the G1 phase of the cell cycle. At this point, the catalytic subunit of a protein kinase (encoded by the CDC28 gene in budding yeast or the homologous CDC2 gene in other eukaryotes) is activated by binding to a positively acting regulatory subunit, a cyclin. Recent research has revealed evidence for two pathways that might connect these kinases to the proteins that replicate DNA: activation of an essential replication factor, or removal of the block that limits genome duplication to once per cell cycle.

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Cell CycleCyclinsDNA ReplicationEukaryotic CellsProtein KinasesJournal ArticleReview

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J M Roberts. 1993. Turning DNA replication on and off.. https://doi.org/10.1016/0955-0674(93)90103-w

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