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Doing the right thing: feedback control and p53.

C Prives
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Abstract

Recent evidence suggests that exposure of cells to DNA-damaging agents causes a rise in the levels of the p53 tumor suppressor protein and arrest of progression through the cell cycle. p53 may therefore resemble a member of the RAD gene class identified in yeast, RAD9, which allows cells to repair DNA before continuation of the cell cycle. The evidence that p53 is a sequence-specific, DNA-binding protein that can regulate transcription suggests several ways in which p53 might effect this growth cessation.

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DNA RepairDNA ReplicationDNA-Binding ProteinsFeedbackHumansTumor Suppressor Protein p53Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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C Prives. 1993. Doing the right thing: feedback control and p53.. https://doi.org/10.1016/0955-0674(93)90105-y

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