PubMed · 8510841
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M M Bailey, R Arbour. 1993. Getting through your first code.. https://doi.org/10.1097/00152193-199306000-00022
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Behavioral medicine is a rapidly developing interdisciplinary field that integrates the biological and psychosocial perspectives of human behavior and apply them to practice of medicine. The aim of behavioral medicine is to analyse, prevent and treat reversible, non-adaptive behavioral patterns, reactions and symptoms. In the early stages of chronic non-infectious illnesses of great epidemiological significance reversible regulation disturbances, non-adaptive behavioral factors (such as smoking, alcohol abuse, etc.) are the most important risk factors, which are closely connected with emotional disturbances, anxiety, depressive symptomatology, hopelessness and learned pathological reactions. Behavioral medicine deals with the recognition, effective treatment and scientific model of these behavioral and psychological problems on different fields of medical practice.
OBJECTIVE: To investigate whether maternal anxiety in the third trimester is associated with an increased uterine artery resistance index. DESIGN: Cohort based study. SUBJECTS: 100 pregnant women, with a mean gestation of 32 weeks. OUTCOME MEASURES: Self rating Spielberger questionnaire for state anxiety and trait anxiety, and uterine blood flow waveform patterns as assessed by colour Doppler ultrasound. RESULTS: A significant association was found between uterine artery resistance index and scores for both Spielberger state anxiety and trait anxiety (rs=0.31, P<0.002 and 0.28 P<0.005 respectively). Women with state anxiety scores >40 (n=15) had a higher mean uterine resistance index than those with scores </= 40 (mean difference with mean resistance index 24%, 95% confidence interval 12% to 38%; P<0.0001). Similarly, women with trait anxiety scores >40 (n=32) had a higher mean resistance index than those with scores </= 40, although to a lesser extent. The presence of notches in the waveform pattern produced by uterine artery blood flow was found in 4/15 (27%) women with high state anxiety scores compared with 4/85 (5%) with low anxiety scores (P<0.02). CONCLUSIONS: This study shows an association between maternal anxiety in pregnancy and increased uterine artery resistance index. It suggests a mechanism by which the psychological state of the mother may affect fetal development, and may explain epidemiological associations between maternal anxiety and low birth weight. The influence of maternal anxiety may be one mechanism by which the intrauterine environment contributes to later disease in offspring.