alpha-Latrotoxin receptor. Implications in nerve terminal function.

A G Petrenko

doi:10.1016/0014-5793(93)81418-y

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alpha-Latrotoxin receptor. Implications in nerve terminal function.

A G Petrenko

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Abstract

alpha-Latrotoxin is a potent stimulator of neurotransmitter release from nerve terminals. High affinity membrane alpha-latrotoxin receptor was purified in an active binding form. It is a membrane glycoprotein (M(r) 160,000-220,000) which may be complexed to a smaller polypeptide (M(r) 29,000). The structure of the receptor protein suggests that it may be a synapse-specific cell recognition molecule. Intracellularly, the alpha-latrotoxin receptor interacts with synaptotagmin, a calcium- and phospholipid-binding protein specifically localized in the synaptic vesicle membrane. This interaction may be important for targeting of synaptic vesicles to presynaptic release sites.

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Animals Calcium-Binding Proteins Cloning, Molecular Membrane Glycoproteins Molecular Structure Nerve Endings Nerve Tissue Proteins Receptors, Cholinergic Receptors, Peptide Synaptotagmins Journal Article Research Support, Non-U.S. Gov't Review

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A G Petrenko. 1993-06-28. alpha-Latrotoxin receptor. Implications in nerve terminal function.. https://doi.org/10.1016/0014-5793(93)81418-y

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