Monitor lyophilization with mass spectrometer gas analysis.

J P Connelly; J V Welch

PubMed · 8515347

Monitor lyophilization with mass spectrometer gas analysis.

Abstract

This paper presents a brief review of the basic issues of lyophilization and the fundamentals of quadrupole mass spectrometry. The emphasis of the paper is on the application of a quadrupole mass spectrometer as a process monitor. The details of sampling and data collection are discussed. Data taken while monitoring lyophilization is presented in conjunction with cycle optimization, end point detection and contaminant detection.

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J P Connelly, J V Welch. Monitor lyophilization with mass spectrometer gas analysis.. https://pubmed.ncbi.nlm.nih.gov/8515347/

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