Characterization and modeling of membrane proteins using sequence analysis.

R A Reithmeier

doi:10.1016/0959-440x(95)80034-4

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Characterization and modeling of membrane proteins using sequence analysis.

R A Reithmeier

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Abstract

The current libraries of amino acid sequences of membrane proteins are a valuable resource for the analysis of elements common to these proteins. Multiple-sequence alignment techniques and the identification of conserved features of transmembrane segments have improved the prediction of membrane protein topology. Molecular modeling in combination with structural studies or site-directed mutagenesis is proving to be a powerful link between theory and experiment. Unfortunately, the number of high-resolution structures of intrinsic membrane proteins, although increased recently, presents a restricted and perhaps biased view of membrane protein structure.

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R A Reithmeier. 1995. Characterization and modeling of membrane proteins using sequence analysis.. https://doi.org/10.1016/0959-440x(95)80034-4

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