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PubMed · 8533150

The base excision repair pathway.

E Seeberg·L Eide·M Bjørås
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Abstract

The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.

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AdenineAlkylationAmino Acid SequenceBase CompositionCytosineDNA DamageDNA RepairEndodeoxyribonucleasesHydrolysisModels, GeneticMolecular Sequence DataN-Glycosyl HydrolasesPurinesUracilJournal ArticleResearch Support, Non-U.S. Gov'tReview

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E Seeberg, L Eide, M Bjørås. 1995. The base excision repair pathway.. https://doi.org/10.1016/s0968-0004(00)89086-6

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