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Perspectives and future directions. Immunogenetics.

R Grubb
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Abstract

An outline of the history of immunogenetics is presented. The usefulness of the Rh, HLA and Gm systems in disease prediction and prevention will increase with our capacity precisely to relate polymorphic variants to particular functions and pathophysiological events. Alloimmunization to Gm markers is common in rheumatoid arthritis, an allegedly autoimmune disease. This paradox and the paradox of nonnominal allotypes, disobeying Mendelian rules, are resolved by the interpretation that herpesviruses may transfer nonself polymorphic genes. Transduction of such genes may be important also in AIDS pathogenesis.

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Autoimmune DiseasesBlood Group AntigensDisease SusceptibilityForecastingGenetic Predisposition to DiseaseHLA AntigensHistory, 20th CenturyHumansImmunogeneticsImmunoglobulin AllotypesRh-Hr Blood-Group SystemRisk AssessmentVirus DiseasesHistorical ArticleJournal Article

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R Grubb. 1995. Perspectives and future directions. Immunogenetics.. https://doi.org/10.1159/000424874

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