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Hepatitis C. A clinical update.

Abstract

Hepatitis C virus is now known to be the causative agent for at least 90% of non-A, non-B hepatitis cases. In the few years since its characterization, much has been learned about this virus and the scope of its disease. It now appears that close to 100% of infections may become chronic, with delayed but potentially devastating consequences. The treatment options for hepatitis C remain limited and less than satisfactory. A vaccine seems to be a distant goal, but other strategies for treatment may be closer. For now, the best option remains prevention.

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BibTeXRIS

S D Colquhoun. 1996. Hepatitis C. A clinical update.. https://doi.org/10.1001/archsurg.1996.01430130020004

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The long-term effect of multidisciplinary back training: a systematic review.

STUDY DESIGN: Systematic review of randomized controlled trials. OBJECTIVES: To determine the long-term effect of multidisciplinary back training on the work participation of patients with nonspecific chronic low back pain. SUMMARY OF BACKGROUND DATA: Chronic low back pain is influenced by multiple factors. Multidisciplinary back training represents one of the options to take this multiplicity into account. So far, only evidence of the short-term effectiveness of this approach in terms of work participation is available. METHODS: Electronic databases were searched and the references of various articles were screened for relevant publications. Ten studies met the inclusion criteria. All included studies were evaluated for their methodologic quality. RESULTS: Five of the studies had a low methodologic quality. All high-quality studies found a positive effect on at least one of the 4 outcome measures used. Based on our criteria, effectiveness was found for the outcome measures of work participation and quality of life. No effectiveness was found for experienced pain and functional status. The intensity of the intervention seems to have no substantial influence on the effectiveness of the intervention. CONCLUSION: In the long-term, multidisciplinary back training has a positive effect on work participation in patients with nonspecific chronic low back pain.

Chronic Disease↗