[Overexpressed p53 protein and cell-proliferative activity disappear or remarkably decrease in neoplastic CGA-positive endocrine and Paneth cells in cancer or dysplasia of ulcerative colitis].

K Matsuda; H Watanabe; T Ohta; Y Ajioka

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PubMed · 8558776

[Overexpressed p53 protein and cell-proliferative activity disappear or remarkably decrease in neoplastic CGA-positive endocrine and Paneth cells in cancer or dysplasia of ulcerative colitis].

K Matsuda·H Watanabe·T Ohta·Y Ajioka

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Abstract

We examined over-expression of p53 protein and proliferative activity of neoplastic endocrine and Paneth cells in cancer or dysplasia of ulcerative colitis (UC). The labeling index of p53 or Ki-67 of endocrine cells was counted with double immunostaining of p53 or Ki-67 and chromogranin A (CGA). 540 CGA-positive cells and 65 Paneth cells were all negative for p53. 5.1% of CGA-positive cells and none of 56 Paneth cells were positive for Ki-67 reaction. These observation suggest that even in cancer or dysplasia of UC cell-differentiation to neoplastic endocrine and Paneth cells decrease proliferative activity, and that these types of cell-differentiation suppress over-expression of p53 protein.

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Cell Division Chromogranin A Chromogranins Colitis, Ulcerative Colon Colonic Neoplasms Female Humans Male Middle Aged Tumor Suppressor Protein p53 English Abstract Journal Article

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K Matsuda, H Watanabe, T Ohta, Y Ajioka. 1995. [Overexpressed p53 protein and cell-proliferative activity disappear or remarkably decrease in neoplastic CGA-positive endocrine and Paneth cells in cancer or dysplasia of ulcerative colitis].. https://pubmed.ncbi.nlm.nih.gov/8558776/

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