Reliability of sequential naloxone challenge tests.

M I Rosen; T J McMahon; A Margolin; T S Gill; S W Woods; H R Pearsall; M J Kreek; T R Kosten

doi:10.3109/00952999509002710

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PubMed · 8561097

Reliability of sequential naloxone challenge tests.

M I Rosen·T J McMahon·A Margolin·T S Gill·S W Woods·H R Pearsall·M J Kreek·T R Kosten

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Abstract

To determine the reliability of serial naloxone challenges, five heroin addicts stabilized on methadone were given 0.2 mg naloxone intravenously on three consecutive days. Two-factor ANOVA revealed that the between-subjects effect accounted for at least 63% of the variance in each of the dependent measures, and the effect of challenge number for at most 22%. Withdrawal tended to be slightly more severe for the first challenge. Intraclass correlation coefficients were calculated for the area-under-the-curve of the change from baseline: subject-rated (.74) and observer-rated (.71) withdrawal, pulse (.88), systolic blood pressure (.58), diastolic blood pressure (.85), and skin temperature (.63).

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Adrenocorticotropic Hormone Adult Blood Pressure Humans Injections, Intravenous Male Methadone Naloxone Narcotic Antagonists Narcotics Reproducibility of Results Severity of Illness Index Substance Withdrawal Syndrome Substance-Related Disorders Journal Article Research Support, U.S. Gov't, P.H.S.

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M I Rosen, T J McMahon, A Margolin, T S Gill, S W Woods, H R Pearsall, M J Kreek, T R Kosten. 1995. Reliability of sequential naloxone challenge tests.. https://doi.org/10.3109/00952999509002710

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