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PubMed · 8562919

Inflammatory cell participation in coagulation.

D C Altieri
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Abstract

Vascular cells, and leukocytes in particular, have evolved a formidable machinery to initiate and amplify coagulation. Through multiple, receptor-mediated recognitions this process provides a cellular microenvironment of limited proteolytic activation that contributes to the maintenance of the hemostatic balance in vivo. However, the ability of leukocytes to generate thrombin is also a fundamental aspect of inflammatory responses, and has far-reaching implications in the pathophysiology of vascular diseases. The scope of this article is to revisit the most recent contributions to the cellular and molecular mechanisms of leukocyte-mediated coagulation, and to highlight their role in the pathogenesis of vascular injury.

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Blood CoagulationForecastingHumansInflammationLeukocytesVascular DiseasesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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D C Altieri. 1995. Inflammatory cell participation in coagulation.. https://doi.org/10.1006/scel.1995.0036

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