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PubMed · 8569732

Membrane phospholipids and adrenergic receptor function.

S Williams·J T Meij·V Panagia
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Abstract

We have reviewed the effects on adrenergic receptors by membrane phospholipid alterations secondary to oxidative stress and phospholipases' activity. Experimental evidences indicate that the function of both alpha- and beta-adrenoceptors is regulated by their phospholipid microdomain; however, the underlying mechanism is still undefined. No information seems to be available on the influence of phospholipids on alpha 2-adrenoceptors and on all adrenoceptors' subtypes. Thus, further studies are necessary to clarify the role of membrane phospholipids in regulating the function of each member of the adrenergic receptor superfamily.

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AnimalsCalciumCyclic AMPMembrane LipidsPhospholipasesPhospholipidsReceptors, Adrenergic, alphaReceptors, Adrenergic, betaSecond Messenger SystemsSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S Williams, J T Meij, V Panagia. Membrane phospholipids and adrenergic receptor function.. https://doi.org/10.1007/bf01076580

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