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PubMed · 8571449

Cooperativity: over the Hill.

S Forsén·S Linse
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Abstract

Cooperativity, the ability of ligand binding at one site on a macromolecule to influence ligand binding at a different site on the same macromolecule, is a fascinating biological property that is often poorly explained in textbooks. The Hill coefficient is commonly used in biophysical studies of cooperative systems although it is not a quantitative measure of cooperativity. The free energy of interaction between binding sites (delta delta G) is a more stringent definition of cooperativity and provides a direct quantitative measure of how the binding of ligand at one site affects the ligand affinity of another site.

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Binding SitesCalbindinsCalciumChemical PhenomenaChemistry, PhysicalLigandsMathematicsS100 Calcium Binding Protein GThermodynamicsJournal Article

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S Forsén, S Linse. 1995. Cooperativity: over the Hill.. https://doi.org/10.1016/s0968-0004(00)89115-x

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