The structural basis of nuclear function.

D A Jackson; P R Cook

doi:10.1016/s0074-7696(08)61230-9

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The structural basis of nuclear function.

D A Jackson·P R Cook

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Abstract

Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.

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Animals Cell Nucleus Chromatin DNA-Directed DNA Polymerase DNA-Directed RNA Polymerases Humans Nuclear Matrix Protein Conformation Journal Article Research Support, Non-U.S. Gov't Review

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D A Jackson, P R Cook. 1995. The structural basis of nuclear function.. https://doi.org/10.1016/s0074-7696(08)61230-9

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