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trans-splicing: an update.

T W Nilsen
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Abstract

5'-end maturation of messenger RNAs via acquisition of a trans-spliced leader sequence occurs in several primitive eukaryotes, some of which are parasitic. This type of trans-splicing proceeds though a two-step reaction pathway directly analogous to that of cis-splicing and like cis-splicing it requires multiple U snRNP cofactors. This minireview attempts to provide a brief synopsis of our current understanding of the evolution and biological significance of trans-splicing. Progress in deciphering the mechanism of trans-splicing, particularly as it relates to current models of cis-splicing, is also discussed.

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AnimalsBiological EvolutionCaenorhabditis elegansPhylogenyRNA PrecursorsRNA SplicingRNA, HelminthRNA, ProtozoanRibonucleoproteins, Small NuclearTrypanosoma brucei bruceiJournal ArticleReview

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T W Nilsen. 1995. trans-splicing: an update.. https://doi.org/10.1016/0166-6851(94)00107-x

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