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PubMed · 857857

Pathophysiological changes in serum erythropoiesis stimulating activity.

J A Napier·C D Dunn·T W Ford·V Price
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Abstract

The mouse fetal liver cell bioassay has been used to study serum levels of erythropoiesis stimulating activity (ESA) in patients with a variety of haematological disturbances. The results indicate that this assay system provides a quantitative measurement of ESA, the concentration of which varies predictably in a manner which is consistent with it having a function as an in vivo regulator of erythropoiesis. Dose-response curves for serum ESA show highly significant parallelism with those obtained from sheep plasma erythropoietin and the International Reference Preparation of human urinary erythropoietin.

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AnemiaAnimalsBlood Cell CountBlood DonorsErythropoiesisErythropoietinHumansMiceRabbitsTime FactorsJournal Article

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J A Napier, C D Dunn, T W Ford, V Price. 1977. Pathophysiological changes in serum erythropoiesis stimulating activity.. https://doi.org/10.1111/j.1365-2141.1977.tb00600.x

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