PubMed · 8588758
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J Rosenblatt, J Murtagh. 1995. Hormone replacement therapy.. https://pubmed.ncbi.nlm.nih.gov/8588758/
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BACKGROUND: The mechanisms causing postmenopausal vasomotor symptoms are unknown, but changes in hypothalamic beta-endorphins have been suggested to be involved. beta-endorphin production may be increased by regular physical exercise. OBJECTIVE: To assess if physically active women suffered from vasomotor symptoms to a lower extent than sedentary women. MATERIAL AND METHODS: All women (n = 1323) in the ages ranging from 55-56 years in the community of Linköping Sweden, were included. In a questionnaire these women were asked about their physical exercise habits and their complaints from vasomotor symptoms. Only those 793 women who had reached a natural menopause were grouped into sedentary, moderately or highly active women, based on a physical activity score. RESULTS: Only 5% of highly physically active women experienced severe hot flushes as compared with 14-16% of women who had little or no weekly exercise (P < 0.05; relative risk 0.26; CI 95%: 0.10-0.71). This was not explained by differences in body mass index, smoking habits or use of hormone replacement therapy. Women who used hormone replacement therapy were more physically active than non-users (P < 0.05). CONCLUSION: Fewer physically active women had severe vasomotor symptoms compared with sedentary women. This may be due to a selection bias but also to the fact that physical exercise on a regular basis affects neurotransmitters which regulate central thermoregulation.
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The author analyzed the data of 122 climacteric patients, getting a fix combination, continuous hormone replacement therapy, having an initial, a 6 month and a 12 month vaginal hormone smear and telling the opinion on the efficacy of the treatment. According to the data, the author registered a significant improvement of the climacteric complaints after a 6 month treatment period. The author considers the vaginal hormone smear an easy and effective method to follow the hormonal state of the climacteric patients. It is advisable to spread this procedure more widely, than it is to day.