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PubMed · 8591900

A new rabbit model for keratoconjunctivitis sicca.

J P Gilbard·S R Rossi·K L Gray
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Abstract

The authors created a new rabbit model for keratoconjunctivitis sicca by cauterizing the lacrimal gland excretory duct and surgically removing the nictitating membrane and harderian gland. Although the slit-lamp examination findings remained normal for the first 8 wk postoperatively, tear-film osmolarity was elevated by postoperative day 1. Corneal epithelial glycogen levels declined progressively, and conjunctival goblet cell density remained decreased. Multiple controls indicated that closure of the lacrimal gland excretory duct was required for elevation of tear film osmolarity, which, in turn, was required for persistent ocular surface disease.

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AnimalsDisease Models, AnimalFemaleHarderian GlandKeratoconjunctivitis SiccaLacrimal ApparatusLacrimal Duct ObstructionMaleNictitating MembraneOsmolar ConcentrationRabbitsTearsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J P Gilbard, S R Rossi, K L Gray. 1987. A new rabbit model for keratoconjunctivitis sicca.. https://pubmed.ncbi.nlm.nih.gov/8591900/

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