Signalling pathways in cardiac failure.

R J Summers; L R McMartin; A Kompa; X Gu; P Molenaar

doi:10.1111/j.1440-1681.1995.tb01954.x

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PubMed · 8593748

Signalling pathways in cardiac failure.

R J Summers·L R McMartin·A Kompa·X Gu·P Molenaar

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Abstract

UNLABELLED: 1. Cardiac failure in humans and in animal models is associated with a marked desensitization of the catecholamine signalling pathway. 2. Beta 1- and beta 2- and possibly beta 3-adrenoceptors (beta-AR) are found in the hearts of humans and common laboratory animals such as rats and guinea-pigs. In rats and guinea-pigs chronic stimulation of cardiac beta-AR leads to a rapid loss of beta 2-AR whereas heart failure in humans is associated with a loss of beta 1-AR or beta 1-AR and beta 2-AR. 3. Desensitization is also associated with phosphorylation of beta-AR by beta-AR kinase (beta-ARK) and uncoupling of receptors from the signalling pathway. Beta-ARK but not beta-arrestin activity and mRNA are markedly increased in heart failure. 4. Chronic beta-AR stimulation and heart failure are associated with increases in Gi alpha but little if any change in Gs alpha. 5. The roles of beta gamma subunits of G-proteins, adenylate cyclase subtypes and cAMP dependent protein kinase A in heart failure are unclear at present. ABBREVIATIONS: beta-ARK - beta-adrenoceptor kinase AR - adrenoceptor G-protein - GTP binding protein

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Animals Cardiac Output, Low GTP-Binding Proteins Guinea Pigs Myocardium Rats Receptors, Adrenergic, beta Signal Transduction Journal Article Research Support, Non-U.S. Gov't

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R J Summers, L R McMartin, A Kompa, X Gu, P Molenaar. 1995. Signalling pathways in cardiac failure.. https://doi.org/10.1111/j.1440-1681.1995.tb01954.x

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