Immunological memory and protective immunity: understanding their relation.

R Ahmed; D Gray

doi:10.1126/science.272.5258.54

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PubMed · 8600537

Immunological memory and protective immunity: understanding their relation.

R Ahmed·D Gray

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Abstract

The immune system can remember, sometimes for a lifetime, the identity of a pathogen. Understanding how this is accomplished has fascinated immunologists and microbiologists for many years, but there is still considerable debate regarding the mechanisms by which long-term immunity is maintained. Some of the controversy stems from a failure to distinguish between effector and memory cells and to define their roles in conferring protection against disease. Here the current understanding of the cellular basis of immune memory is reviewed and the relative contributions made to protective immunity by memory and effector T and B cells are examined.

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Animals Antibody Formation Antigens B-Lymphocytes CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Differentiation Cell Lineage Humans Immunologic Memory Infections Lymphocyte Activation Plasma Cells Receptors, Antigen, T-Cell T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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R Ahmed, D Gray. 1996-04-05. Immunological memory and protective immunity: understanding their relation.. https://doi.org/10.1126/science.272.5258.54

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