Sphenoid sinus malignancies.

P J Donald; J E Boggan

doi:10.1097/00001665-199501000-00007

Home/Archive/PubMed

PubMed · 8601000

Sphenoid sinus malignancies.

P J Donald·J E Boggan

View original source ↗Export metadata ↓

Abstract

The sphenoid sinus has traditionally been considered a poorly accessible structure, situated deep in the center of the head and surrounded by vital structures. Aggressive benign and malignant tumors are usually considered to be inoperable because of the proximity of such structures, thus precluding the possibility of total extirpation. Using the transfacial-subcranial approach, lesions at this site can be totally excised. Significant tumor-free survival rates can be anticipated.

Explore related subjects

Carcinoma, Mucoepidermoid Carcinoma, Squamous Cell Cavernous Sinus Craniotomy Disease-Free Survival Ethmoid Sinus Head and Neck Neoplasms Humans Neoplasm Invasiveness Neoplasm Recurrence, Local Nose Papilloma, Inverted Paranasal Sinus Neoplasms Patient Care Planning Patient Care Team Prognosis Sphenoid Sinus Survival Rate Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

P J Donald, J E Boggan. 1995. Sphenoid sinus malignancies.. https://doi.org/10.1097/00001665-199501000-00007

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells.

OBJECTIVES: Mucin gene expression and mucin production are markedly increased in inflammatory airway disorders such as asthma, chronic bronchitis and rhinosinusitis. Cytokines, lipopolysaccharides and other inflammatory mediators such as prostaglandin and leukotriene are related to the secretion and production of mucin. However, the relationship of leukotrienes with mucin genes expression is not clear. The aim of this study is to evaluate MUC2/5AC gene expression and mucin secretion by the leukotriene receptor in human airway epithelial cells. METHODS: The effect of leukotriene D(4) and the leukotriene receptor antagonist, pranlukast hydrate (ONO-1078) on the regulation of MUC2/5AC gene expression and mucin secretion were observed in human airway NCI-H292 epithelial cells. The mRNA levels of MUC2/5AC and the amount of mucin were determined by reverse transcription-polymerase chain reaction (RT-PCR) and immunoassay. RESULTS: Leukotriene D(4) upregulated MUC2/5AC gene expression and mucin secretion in a dose dependent pattern. Pranlukast hydrate (ONO-1078, 100 microM) downregulated the leukotriene D(4)-induced MUC2/5AC gene expression and mucin secretion. CONCLUSION: These results suggest that the leukotriene receptor system is one of the mechanisms related to MUC2/5AC gene expression and mucin secretion in the human airway epithelium.

Carcinoma, Mucoepidermoid↗

PubMed2006

Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer.

Explore the source record for details and available documents.

Carcinoma, Mucoepidermoid↗

PubMed2006

A diagnostic pitfall: nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis mimicking a sclerosing mucoepidermoid carcinoma with eosinophilia.

Nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis is an exceptional, benign condition presenting diagnostic difficulties for the pathologist. The main differential diagnosis is a sclerosing mucoepidermoid carcinoma (SMC) with eosinophilia. One case arising in a 50-year-old Caucasian man is reported. Histologically, the nodule consisted of large nests of squamous cells surrounded by connective tissue in Hashimoto's thyroiditis. We present the different histological criteria, allowing us to eliminate an SMC and other neoplastic tumors of the thyroid. The etiology of this tumor-like lesion, which is still under debate, is discussed.

Carcinoma, Mucoepidermoid↗